| 杨照华,孙梅贞,倪震黎,等.双分子取代苯酚类螯合剂的合成及对放射性钍的促排效果研究[J].中华放射医学与防护杂志,1997,17(3):178-181.Yang Zhaohua,Sun Meizhen,Ni Zhenli,et al.Synthesis of bimolecule substituted phenols and their effect on rats for removal of radiothorium[J].Chin J Radiol Med Prot,1997,17(3):178-181 |
| 双分子取代苯酚类螯合剂的合成及对放射性钍的促排效果研究 |
| Synthesis of bimolecule substituted phenols and their effect on rats for removal of radiothorium |
| 投稿时间：1996-12-16 修订日期：1997-01-25 |
| DOI： |
| 中文关键词: 螯合剂 钍-234 促排药 |
| 英文关键词:Chelating agents Thorium-234 Decorporation drug |
| 基金项目:国家自然科学基金 |
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| 中文摘要: |
| 目的 本文旨在寻找新的治疗用螯合剂, 以加速排除沉积在体内的放射性钍, 达到放射防护的目的。方法 首先通过Mannich反应合成双分子取代苯酚类螯合剂, 然后经动物实验:SD大鼠静脉中毒234Th后立即肌注药物, 2天后解剖动物测定234Th量, 计算排出量和蓄积量, 研究其促排效果。结果 所报道的螯合剂不仅能增加大鼠在尿、粪中234Th的排除, 同时能降低在肝、骨中的蓄积, 呈现较好的促排效果。其中以化合物Ⅷ促排效果最好, 2天后可排除68%的234Th;在肝、骨中的沉积仅为11.7%, 而对照组则是87.6%.结论 螯合剂Ⅷ值得进一步研究探讨。 |
| 英文摘要: |
| Objectives To search for new therapeutic chelating agents for removal of incorporated radiothorium. Methods New chelating agents (bimolecule-substituted phenols) were synthesized through Mannich reaction.These compounds were administered i.m.to SD rats after i.v.injection of 234Th .Two days later the radiothorium was assayed and the excretion and retention rates were calculated.Results These chelating agents could increase the excretion of 234Th in urine and feces and decrease its retention in liver and skeleton of rats.Among them No.Ⅷ is the best one, which could promote excretion of 68%. 234Th after two days and the retention of 234Th deposited in the tissues (liver and skeleton) was only 11.7%, as compared with 87.6% in the control group. Conclusions The chelating agent No.Ⅷ is worth further investigation. |
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