| 秦凤华,范永星,孙志贤,等.OK-432对小鼠γ射线照射后T淋巴细胞功能的修复作用[J].中华放射医学与防护杂志,1997,17(2):102-104.QIN Fenghua,FAN Yongxing,SUN Zhixian,et al.OK 432 accelerates recovery of T lymphocyte functions in mice following sublethal γ ray irradiation[J].Chin J Radiol Med Prot,1997,17(2):102-104 |
| OK-432对小鼠γ射线照射后T淋巴细胞功能的修复作用 |
| OK 432 accelerates recovery of T lymphocyte functions in mice following sublethal γ ray irradiation |
| 投稿时间：1995-09-15 修订日期：1996-03-13 |
| DOI： |
| 中文关键词: 溶血性链球菌制剂（OK－432） γ射线照射 T淋巴细胞 免疫功能 |
| 英文关键词:Streptococcus haemolyticus（OK 432） γ Ray irradiation T lymphocytes Immunologic function |
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| 中文摘要: |
| 目的 对溶血性链球菌制剂OK-432促进照射小鼠T细胞功能的修复作用进行了探讨。方法 实验用BALb/c小鼠,60Coγ射线一次全身照射,吸收剂量5 Gy。观察指标:小鼠脾淋巴细胞转化;IL-2产生及活性测定;迟发型超敏反应性测定。结果 OK-432对几个T细胞亚群均具有作用,促进受照射小鼠对同种异型脾细胞的混合淋巴细胞反应及迟发型超敏反应的修复,促进脾脏中TH细胞产生IL-2,并能增强脾细胞对非特异性有丝分裂原的增殖反应。结论 OK-432有促进多种T细胞亚群功能恢复的作用。 |
| 英文摘要: |
| The effect of OK 432 a preparation of streptococcus haemolyticus,on accelerating the recovery of T lymphocyte function in mice after γ irradiation has been studied.The result indicates that OK 432 has effects on several subpopulations of T lymphocytes.It can promote the recovery of mixed lymphocyte reaction （MLR） and delayed type hypersensitivity to allotype splenocytes in irradiated mice,increase the production of IL 2 by T H lymphocytes and the proliferation response of splenocytes to non specific mitogen Con A. |
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