| 白蕴红,王德文,龚诒芬,葛桂秀,张振声,崔雪梅,杨陟华,熊呈琦,朱茂祥,李延平.富硒制剂对放射性肺炎早期效果的初步研究[J].中华放射医学与防护杂志,1997,17(2):88-90 |
| 富硒制剂对放射性肺炎早期效果的初步研究 |
| Early effects of selenium preparation on radiation pneumonia |
| 投稿时间：1996-03-18 修订日期：1996-05-30 |
| DOI： |
| 中文关键词: 放射 肺炎 胶原 病理观察 富硒制剂 |
| 英文关键词:Radiation pneumonia Collagens Pathological study Selenium |
| 基金项目: |
| 作者 | 单位 | | 白蕴红 | 100850, 北京放射医学研究所 | | 王德文 | 100850, 北京放射医学研究所 | | 龚诒芬 | 100850, 北京放射医学研究所 | | 葛桂秀 | 100850, 北京放射医学研究所 | | 张振声 | 100850, 北京放射医学研究所 | | 崔雪梅 | 100850, 北京放射医学研究所 | | 杨陟华 | 100850, 北京放射医学研究所 | | 熊呈琦 | 100850, 北京放射医学研究所 | | 朱茂祥 | 100850, 北京放射医学研究所 | | 李延平 | 100850, 北京放射医学研究所 |
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| 中文摘要: |
| 目的 为给防治放射性肺炎的药物研究提供实验依据,作者观察了富硒制剂对大鼠早期放射性肺炎的效果。方法 雄性Wistar大鼠48只分为对照组,单纯照射组,补硒照射组。γ射线照射,吸收剂量15 Gy,于0.5,1,2,3个月活杀取肺组织做光镜观察和肺组织RNA提取,应用斑点杂交和图像分析技术测Ⅰ和Ⅲ型肺胶原mRNA含量。结果 照射组大鼠肺损伤明显,而富硒制剂使肺充血、出血、渗出性变化及肺泡壁增厚程度减轻,且对肺Ⅰ(Ⅲ)型胶原mRNA合成有一定程度的抑制作用。结论 富硒制剂对大鼠早期放射性肺炎有防治效果。 |
| 英文摘要: |
| Objective In order to provide experimental basis for drug efficacy of preventing and treating radiation pneumonia,the authors observed the early effects of selenium preparation on the radiation pneumonia.Method Wistar male rats were divided into three groups of 48 rats:the control group,the irradiated group and the irradiated plus selenium preparation treated group.The animals received thoracic irradiation of 15 Gy,and were killed at 0.5,1,2,3 months post irradiation.Lung tissues were processed for light microscopy and isolation of RNA.Expression of type Ⅰ（Ⅲ） collagen was evaluated by dot blot hybridization and image analysis technique.Results Pathological study showed marked lung injury in the irradiated group while only slight hyperemia,hemorrhage,exudation and thickeness of alveolar walls in the lungs of selenium preparation treated group.The synthesis of type Ⅰ and Ⅲ collagen mRNA also decreased in the selenium preparation treated group.Conclusion Selenium preparation could have protective and therapeutic effects on radiation pneumonia. |
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