| 林星石,刘亚莉,张笑明,夏红天,孙晓华,宋琛,袁玫.复方樟柳碱治疗大鼠急性放射性间质性肺炎的病理形态学研究[J].中华放射医学与防护杂志,1997,17(2):77-79 |
| 复方樟柳碱治疗大鼠急性放射性间质性肺炎的病理形态学研究 |
| Treatment of radiation-induced interstitial pneumonia in rats with compound anisodine on pathological study |
| 投稿时间：1996-05-02 修订日期：1996-10-08 |
| DOI： |
| 中文关键词: 放射性间质性肺炎 复方樟柳碱 病理形态学 |
| 英文关键词:Radiation-induced interstitial pneumonia Anisodine Pathological study |
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| 中文摘要: |
| 目的 放射性间质性肺炎是辐射伤的一种严重并发症。为更有效的防治,作者首次用复方樟柳碱(CA)来治疗大鼠的放射性肺炎。方法 45只Wistar鼠随机分成3组:(1)照射组;(2)CA防治组;(3)正常对照组。(1)和(2)组鼠接受单次全胸60Coγ射线30 Gy照射。(2)组照射前两天开始进行CA治疗,1次/天,直至与其他组分别于15,30,45天处死。结果 病理形态学显示:照射组大鼠产生了典型的放射性间质性肺炎,而CA防治组肺组织仅有轻度辐射反应,且迅速恢复。结论 用复方樟柳碱预防治疗早期大鼠放射性间质性肺炎是有效的,其能保护肺组织,减轻因辐射所致的肺损伤。 |
| 英文摘要: |
| Objective Interstitial pneumonia is a severe complication of radiation injury.In order to improve the therapeutic efficacy,we used compound anisodine （CA） to prevent and treat the radiation-induced pneumonia in rats. Method 45 Wistar rats were randomly divided into three groups: radiated group,CA treated group,and control group.The thoraces of rats in the radiated group and CA treated group received 30 Gy single exposure dose of 60Co γ radiation. On 2 days before irradiation,the rats of CA treated group were injected with CA subcutaneously once a day,until they were killed with other groups on days 15,30,50 after irradiation,respectively. Results The pathological morphology showed that the rats in the radiated group suffered from typical radiation-induced interstitial pneumonia,while the rats in the CA treated group had only slight reactions in their lungs and recovered quickly. Conclusions The experimental results indicate that in the early stage after radiation exposure,treatment and prevention of interstitial pneumonia in rats with CA is effective and CA can protect the lung tissues,prevent and relieve the radiation injury of lungs. |
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