冯乐平,陈军,王献理,苏士杰,董永兰.低剂量辐射诱导肿瘤细胞动力学变化及对丝裂霉素抗肿瘤效应的影响[J].中华放射医学与防护杂志,1996,16(6):393-395 |
低剂量辐射诱导肿瘤细胞动力学变化及对丝裂霉素抗肿瘤效应的影响 |
Effects of low dose irradiation on tumor cell kinetics and anti-tumor efficacy of mitomycin |
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DOI: |
中文关键词: 低剂量辐射(D1) 细胞动力学 丝裂霉素(MMC) 细胞程序化死亡(PCD) |
英文关键词:Low dose irradiation cell kinetics mitomycin programmed cell death |
基金项目:国家自然科学基金 |
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中文摘要: |
目的: 在低剂量照射条件下, 合并化疗, 以观察肿瘤细胞动力学变化。方法: 应用0.05GyX射线对荷瘤鼠全身照射, 结果: 发现肿瘤细胞摄入3H-TdR能力降低, C0/G1期细胞百分数增加, S期细胞百分数下降, G2期出现阻滞现象, 且与对照组比较差异有显着性。低剂量辐射可增强丝裂霉素的化疗效果, 导致肿瘤组织生长明显受抑。结论: 上述结果证明:低剂量辐射可以抑制肿瘤细胞DNA合成, 诱导肿瘤细胞动力学改变, 间接证实这种效应可促使肿瘤细胞向着程序化细胞死亡方向转变。且上述效应均有利于丝裂霉素的抗肿瘤作用。 |
英文摘要: |
The changes of carcinoma cell cycle distribution were induced in vitro and in vivo by low dose(0.05Gy) X-ray irradiation. The percentages of the cells in G0/G1 phases tended to increase and that in S phase decreased. The extent of accumulation of cells in G1 phase was dose associated with programmed cell death (PCD) . It is indirectly showed in this study that low dose X-irradiation can impel the malignant cells to proceed to PCD. The result also demonstrated that low dose X - irradiation enhanced efficacy of mitomycin in killing malignant cells. |
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