| 邱丽玲,柳晓兰,赵振虎,张卿西,毛秉智,王嘉玺,凌世淦.不同剂量重组人IL－6对照射小鼠外周血细胞恢复的影响[J].中华放射医学与防护杂志,1996,16(6):389-392 |
| 不同剂量重组人IL－6对照射小鼠外周血细胞恢复的影响 |
| Effect of different doses of rhIL-6 on peripheral blood recovery in irradiated mice |
| 投稿时间：1996-01-02 修订日期：1996-04-16 |
| DOI： |
| 中文关键词: rhIL－6 照射 外周血细胞恢复 |
| 英文关键词:Recombinant human interleukin-6 γ-ray irradiation peripheral blood count |
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| 摘要点击次数: 2437 |
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| 中文摘要: |
| 目的: 观察了不同剂量rhIL-6对6.5Gy照射C57BL/6J小鼠外周血细胞恢复的影响。方法: IL-6的剂量分别为10, 200, 500和1000μg·Kgt-1·d-1, 连续给药4天, 首次于照后30分钟给入, 皮下注射, 每日两次。照后5, 11, 14, 18, 22和30天测定外周血白细胞、血小板和红细胞数量等变化。结果表明: IL-6的4种剂量治疗组外周血细胞数降至最低值时间与对照组相同即:WBC为5天, PLT为11天, RBC为14天。然而, 在IL-6剂量大于或等于200μg·Kg-1·d-1时, 各组外周血WBC、PLT和RBC的最低值不同程度地高于对照组, 其后的恢复程度也比对照组高。IL-6治疗组外周血三类血细胞最低值及一定时期的恢复程度与IL-6剂量之间有良好的相关关系。结论: 通过本研究, rhIL-6将是治疗辐射引起的血小板生成减少的候选因子之一。 |
| 英文摘要: |
| The effects of recombinant human interleukin-6 (rhIL-6) on the recovery of peripheral blood picture in 6.5Gyγ-ray irradiated( 132-127. 7R/min) C57BL/6J mice at the age of 80-90 days were studied. Group 1 served as the control and groups 2-5 were injected subcutaneously with rhIL-6 twice daily at doses of 10,200,500 and 1000μg -1 kg-1d-1, respectively, starting from 30 min after irradiation for 4 consecutive days. Peripheral WBC, RBC, and PLT counts, hemoglobin and hematocrit were determined before and 5,11,14,18,22 and 30 days after irradiation. It was shown that although the time of nadir emergence and the onset of recovery were similar in all the five groups, the nadir values were higher and the recovery was better, both being dose-dependent, in the IL-6 treated groups than in the control.Significant dose-response regression equations were obtained for WBC count on day 22,for RBC count on days 14 and 18, for PLT count on days 11 and 18.Our studies show that IL-6 is a candidate of thrombopoietic factor for treatment of radiation-induced thrombocytopenia. |
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