| 傅海青,李修义,李有君,刘树铮.低剂量全身照射抑制小鼠癌细胞播散[J].中华放射医学与防护杂志,1996,16(5):307-309 |
| 低剂量全身照射抑制小鼠癌细胞播散 |
| Whole-body low dose irradiation suppresses cancer cell dissemination in mice |
| 投稿时间：1995-10-01 修订日期：1996-02-13 |
| DOI： |
| 中文关键词: 低剂量辐射 癌细胞播散 NK细胞活性 IL－2分泌 |
| 英文关键词:Low dose radiation Cancer cells NK cells IL-2 secretion |
| 基金项目:国家自然科学基金 |
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| 中文摘要: |
| 小鼠受50, 75, 100和150mGyX射线全身照射后24小时经球后静脉注入Lewis肺癌或B16黑色素瘤细胞。注后14天以计数肺肿瘤结节数为指标, 发现受照小鼠癌细胞播散明显低于假照射对照小鼠。Lewis肺癌细胞注入前24小时接受75mGy全身照射小鼠与注入相同癌细胞数的假照射小鼠比较, 发现照后2～6天脾脏NK细胞活性和IL-2分泌均增高。提示低剂量辐射可能通过增强免疫反应抑制癌细胞播散。 |
| 英文摘要: |
| Lewis lung carcinoma or B16melanoma cells were injected into the retrobulbar vein of mice 24h after whole-body irradiation (WBI) with 50, 75 , 100 or 150 mGy X-rays.The dissemination of the cancer cells as evaluated by counting the tumor nodules on the lung surface 14d after injection was found to be markedly decreased in the irradiated rnice as compared with the sham-irradiated control.In mice given 75 mGy WBI 24h before injection of Lewis lung carcinoma cells the splenic NK cell activity and IL-2 secretion were found to be potentiated 2-6 days after irradiation in comparison with the sham-irradiated mice which received the same number of tumor cells.The results suggest that low dose radiation might suppress cancer cell dissemination via the enhancement of immune rcactivity. |
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