| 朱寿彭,王六一,胡启跃,杨卫东.睾丸中滞留的不同辐射体核素诱发生殖毒性比较研究[J].中华放射医学与防护杂志,1996,16(5):302-306 |
| 睾丸中滞留的不同辐射体核素诱发生殖毒性比较研究 |
| Comparative study on retentive peculiarity in testes and reproductive toxicity induced by different radiators |
| 投稿时间：1995-11-28 修订日期：1996-03-13 |
| DOI： |
| 中文关键词: 睾丸 滞留 放射性核素 精子畸形 精原细胞 生殖毒性 |
| 英文关键词:Testes Retention Radionuclides Sperm abnormality Spermatogonia Reproductive toxicity |
| 基金项目:国家自然科学基金 |
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| 摘要点击次数: 2021 |
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| 中文摘要: |
| 探讨了α辐射体浓缩铀(235U)、β辐射体(147Pm)和γ辐射体(134Cs)在睾丸的滞留特性, 诱发生殖细胞精子畸形和精原细胞染色体畸变效应比较研究. 拟合了不同辐射体核素在睾丸中的滞留分数方程, 观察到其半滞留期以235U为最长, 147Pm次之, 134Cs最短, 其值分别为197天, 76天, 5天。研究还给出了三种辐射体核素在每厘戈瑞累积吸收剂量水平诱发精子畸形的生殖毒性比较值α:β:γ为28:3:1;而诱发精原细胞染色体畸变的生殖毒性比较值为29:4:1. |
| 英文摘要: |
| In this paper a comparative study on retentive peculianties of different radiators in testes is reported.The equations fitted to describe the retentive fractions of α radiator 235U and β radiator 147Pm as well as γ radiator 134Cs respectively have been obtained.The half-life components were calculated to be T1/2=197d for 235U, T1/2= 76d for 147Pm, and only 5.1d for134Cs.Comparative study on reproductive toxicity induced by different radiators showed that internal contamination with different radiators could result in sperm abnormality.For different radiators such as 235U,M147Pm and 134Cs, the rates of sperm abnormality induced by 1 cGy cumulative absorption dose were different: the comparative value of reproductive toxicity was α: β:γ= 28 : 3 : 1.Results indicated that internal contamination by different radiatore could damage genetic materials and cause chromosome aberrations in spermatogonia.By comparison between different radiators, the frequencies of chromosome aberrations induced by 1cGy cumulative absorption dose were significantly different: the comparative value of reproductive toxicity was α: β: γ= 29 : 4 :1 . |
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