| 田生礼,丛宪玲,王献理.dsRNA对X射线照射小鼠脾细胞增殖反应和UDS的影响[J].中华放射医学与防护杂志,1996,16(4):246-247 |
| dsRNA对X射线照射小鼠脾细胞增殖反应和UDS的影响 |
| Effects of dsRNA on proliferative reaction and UDS of splenocytes in X-iradiated mice |
| 投稿时间：1994-07-19 修订日期：1995-02-27 |
| DOI： |
| 中文关键词: dsRNA X射线 脾细胞增殖反应 |
| 英文关键词:dsRNA X-rays UDS proliferative reaction splenocytes |
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| 中文摘要: |
| 本文报道了不同浓度dsRNA对1.5GyX射线照射后小鼠脾细胞对ConA和LPS诱导增殖反应和UDS的影响。结果表明, 当受照小鼠皮下注射RNA浓度大于6.25mg/kg体重时与单纯照射组相比脾细胞对ConA和LPS诱导的增殖反应明显增强(P<0.05), UDS亦明显的增加(P<0.05).提示, dsRNA可以增强受照细胞对ConA和LPS诱导的增殖反应能力, 并能抑制X射线诱发程序外DNA合成的下降。 |
| 英文摘要: |
| The effects of different concentratios of dsRNA on proliferative reaction of splenocytes induced by ConA and LPS and on UDS of splenocytes in 1.5Gy X-irradiated mice are reported in this paper.The results showed that the proliferative reaction of splenocytes induced by ConA and LPS in experimental groups increased significantly compared with that in positive group and that UDS in experimental groups was also much enhanced compared with that in positive group when concentration of dsRNA was higher than 6.25mg/kg body weight.It is suggested that dsRNA increases proliferative reaction of splenocytes induced by ConA and LPA and inhibits decrease of UDS induced by X-rays. |
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