| 冉新泽,阎永堂,程天民,等.放射损伤复合烧伤对异体皮存活及某些免疫变化的影响[J].中华放射医学与防护杂志,1996,16(4):228-231.Ran Xinze,Yan Yongtang,Cheng Tianmin,et al.Effects of combined radiation-burn injury on survival rate of allogeneic skin grafts and immune reaction in rats[J].Chin J Radiol Med Prot,1996,16(4):228-231 |
| 放射损伤复合烧伤对异体皮存活及某些免疫变化的影响 |
| Effects of combined radiation-burn injury on survival rate of allogeneic skin grafts and immune reaction in rats |
| 投稿时间：1995-02-13 修订日期：1995-08-14 |
| DOI： |
| 中文关键词: 放烧复合伤 异体植皮 照射剂量 免疫反应 |
| 英文关键词:Combined radiation-bur n injury allogeneic skin graft radiation dose immune reaction |
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| 中文摘要: |
| 本文作者探讨了15%Ⅲ度烧伤复合3～8Gy全身照射对大鼠异体皮存活及其免疫反应的影响。单烧组异体皮10天全部排斥, 早期免疫反应增强；而放烧复合伤时免疫反应明显受抑制, 所植异体皮在复合3Gy或4Gy照射时, 10天存活率分别为20%和30%;复合5, 6, 8Gy者则上升为69%, 88%和100%, 存活至30天仍达36%, 42%和100%, 与单烧植皮组相比, 复合5Gy以上照射者均有显着性差异。表明放烧复合伤时异体皮存活率主要随受照射剂量增加而增高, 随时间后延有所降低。 |
| 英文摘要: |
| The effects of combined radiation-burn injury on survival rate of allogeneic skin grafts and immune reaction were studied in rats with combined injury of 3-8Gy 60Co γ-ray irradiation plus 15% total body surface area full thickness burn induced by exposure to a 5kW bromotungsten lamp.The allogeneic skin was transplanted 24 hours after injury.It was found that all the skin grafts failed to survive in 10 days and the immune reaction significantly increased in the early stage of burn injury.But the immune reaction was obviously suppressed by the combined radiation-burn injury.The survival rates of skin grafts were 20% and 30% in the combined injury of bum plus 3 and 4Gy irradiation respectively.When the radiation doses increased to 5,6 and 8Gy,the survival rates elevated to 69%,88% and 100% respectively(in the group of 8Gy,bone marrow transplantation was conducted before receiving skin graft).At day 30 post-transplantation the survival rates were still 36%,42% and 100% respectively.Compared with burn group,there was a significant difference in survival rate when the radiation doses were higher then 5Gy.These results indicate that the survival rate of the allogeneic skin graft increases concurrently with the increase in radiation dose and decreases with the elapse of the post-transplantaion time. |
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