| 赵坡,王德文,高亚兵,熊呈琦,杨志祥,李国民.人放射性皮肤溃疡MDM2，p53蛋白高表达研究[J].中华放射医学与防护杂志,1996,16(4):223-224 |
| 人放射性皮肤溃疡MDM2，p53蛋白高表达研究 |
| Overexpression of MDM2 and p53 proteins in human radiation-induced skin ulcer |
| 投稿时间：1995-09-14 修订日期：1995-12-22 |
| DOI： |
| 中文关键词: 皮肤溃疡 辐射 癌基因 |
| 英文关键词:Skin ulcer radiation oncogene |
| 基金项目:国家自然科学基金 |
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| 中文摘要: |
| 我们使用MDM2和/p53单克隆抗体和免疫组化方法, 研究了25例人慢性放射性皮肤溃疡, 发现MDM2高表达阳性率为36%(9/25), p53高表达阳性率仅为8%(2/25).结果表明MDM2, p53, 基因和蛋白质的分子病理变化可能参与人放射性皮肤溃疡的癌前病变。 |
| 英文摘要: |
| We used MDM2 and p53 monoclonal antibodies and immunohistochemical method to study 25 cases of human radiation-induced skin ulcer.It was found that the positive rate for overexpression of MDM2 was 36% (9/25)and for that of p53 was only 8% (2/25).The result suggests that the molecular pathological changes in MDM2 and p53,genes and proteins might be involved in cancer transformation of human radiationinduced skin ulcer. |
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