| 杜悦娇,王德文,高亚兵,李国民,赵坡,杨志祥,徐在海.人皮肤慢性放射性溃疡c－fos、Rb蛋白异常高表达病理研究[J].中华放射医学与防护杂志,1996,16(4):220-222 |
| 人皮肤慢性放射性溃疡c－fos、Rb蛋白异常高表达病理研究 |
| A pathological study on overexpression of c-fos and Rb proteins in human radiation skin ulcer |
| 投稿时间：1996-01-15 修订日期：1996-03-30 |
| DOI： |
| 中文关键词: 放射性皮肤损伤 癌基因 病理 |
| 英文关键词:Radiation skin injury oncogene pathology |
| 基金项目:国家自然科学基金 |
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| 摘要点击次数: 2096 |
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| 中文摘要: |
| 作者应用c-fos、Rb蛋白抗体和微波炉抗原修复法对人慢性放射性皮肤溃疡进行免疫组织化学研究。结果显示：①c-fos蛋白在人放射性皮肤溃疡阳性率为84.0%.阳性部位主要见于增生的鳞状上皮细胞核、增生的纤维母细胞以及小血管内皮细胞、小动脉中层平滑肌细胞核, 部分细胞浆内有阳性反应。②将c-fos蛋白在表皮的检出情况及反应强度与表皮的增生程度列表分析, 提示c-fos蛋白在各增生表皮以至癌变组织阳性率有升高趋势。 |
| 英文摘要: |
| We performed an immunohistochemical study on human radiation skin ulcer by using antibodies against c-fos and Rb proteins and antigen-repairing method with a microwave oven.We found that the positive rates of overexpression of c-fos and Rb proteins were 84.0% and 100%,respectively.The overexpression of c-fos protein was mainly observed in cell nuclei of squamous epithelial cells,fibroblasts,endothelial cells,and leiomyocytes in media and fibrocytes in adventitia of arterioles.The location of the Rb protein overexpression was mostly similar to that of c-fos protein.The overexpression of c-fos and Rb proteins may be related to cancer transformation and poor healing of radiation-induced skin ulcers. |
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