| 吕玉民,傅宝华,刘金荣,陈玉浩,任春仙,韩林,赵凤玲,张可军,陈春华.60Coγ射线离体照射人精子诱发染色体畸变的研究[J].中华放射医学与防护杂志,1996,16(3):176-178 |
| 60Coγ射线离体照射人精子诱发染色体畸变的研究 |
| Research of chromosome aberrations in human spermatozoa radiated with60Coγ-rays in vitro |
| 投稿时间：1995-03-21 修订日期：1995-07-14 |
| DOI： |
| 中文关键词: 60Coγ射线离体照射 人精子 去透明带地鼠卵 染色体畸变 |
| 英文关键词:Gamma irradiation human sperm hamster oocytes chromosome aberrations |
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| 中文摘要: |
| 本文作者用60Coγ对线对一名健康男性的精液样本照射处理, 与去透明带地鼠卵受精制备精子染色体核型, 研究离体照射诱发的人精子染色体畸变。结果表明：在0.00,1.01,1.81和2.99Gy剂量点的结构畸变精子率和结构畸变率(Y)均与照射剂量(D)呈非常显着正相关, 回归式分别为Y=6.62+16.11D和Y=5.75+27.33D,精子染色体以染色体型和断裂型畸变为主, 分别是单体型和互换型畸变的11倍和8倍。结果提示：染色体严重受损的精子仍保持较高的受精能力。 |
| 英文摘要: |
| The effets of in vitro 60 Coγ-irradiation on human sperm chromosomes were studied using the interspecific in vitro fertilization system between human spermatozoa and zona-free hamster oocytes.The semen samples from a healthy man were exposed to 0.00, 1.01, 1.81 and 2.99Gy ofγ-rays.The incidence of spermatozoa wthγ-ray-induced structural chromosome aberrations(Y) and structural chromosome abnormalities(Y) increased limearly with increasing dosage(D).being best ex p ressed by the equations Y=6.62+16.11D and Y=5.57+27.33D, respectively.The frequency of breakage-type aberrations was more than & times higher than that of exchange-type aberrations;the frequency of chromosome type aberrations was about 11 times higher than that of chromatid-type aberrations.The results indicated that human sperm retains a high fertilizing ability even after serious chromosomal damage. |
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