| 罗庆良,夏贞彪,董波,等.重组人粒细胞集落刺激因子对6.5Gy不均匀照射狗造血影响的研究[J].中华放射医学与防护杂志,1996,16(3):170-172.Luo Qingliang,Xia Zhenbiao,Dong Bo,et al.Haematological effects of rhG-CSF on dogs exposed to 6.5Gy uneven γ-radiation[J].Chin J Radiol Med Prot,1996,16(3):170-172 |
| 重组人粒细胞集落刺激因子对6.5Gy不均匀照射狗造血影响的研究 |
| Haematological effects of rhG-CSF on dogs exposed to 6.5Gy uneven γ-radiation |
| 投稿时间：1995-03-21 修订日期：1995-07-14 |
| DOI： |
| 中文关键词: rhG－CSF 急性放射病 不均匀照射 |
| 英文关键词:rhG-CSF neutropenia acute radiation sickness uneven irradiation |
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| 中文摘要: |
| 观察了重组人粒细胞集落刺激因子(rhG-CSF)对屏蔽全骨盆后6.5Gy60Coγ射线照射狗的治疗作用。结果表明, rhG-CSF可使急性放射病狗造血恢复明显提前, 恢复速度加快。 |
| 英文摘要: |
| The stimulative effects of recombinant human granulocyte colony stimulating factor(rhG-CSF)on haematopoietic regeneration were studied in dogs receiving an uneven γ-irradiation with the pelvis shielded at a dose of 6.5Gy.In the treated dogs, intravenous administration of rhG-CSF at 5 or 10μg/kg per day for 16 to 20 days caused significant increases of peripheral blood leucocytes, neutrophils, reticulocytes, and platelets.The nucleated cell and CFU-GM cornts of bone marrow also showed an obvious rise, while the hemoglobin level did not significantly change during the course of treatment.In the irradiated dogs treated with rhG-CSF, the severity of neutropenia decreased, and its duration shortened. |
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