| 金慰芳,朱文菁,王洪复,关本博.137Csγ射线照射建立成骨细胞衰老模型的研究[J].中华放射医学与防护杂志,1996,16(3):164-166 |
| 137Csγ射线照射建立成骨细胞衰老模型的研究 |
| Establishing an ageing model of osteoblasts with137Cs γ-ray irradiation |
| 投稿时间：1995-03-21 修订日期：1995-07-14 |
| DOI： |
| 中文关键词: 成骨细胞 γ射线照射 衰老模型 |
| 英文关键词:osteoblasts gamma irradiation ageing model |
| 基金项目:国家自然科学基金 |
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| 中文摘要: |
| 用137Csγ射线照射体外培养的成骨细胞, 可引起成骨细胞功能、增殖率及形态的退行性改变。一次照射6.0Gy,成骨细胞的碱性磷酸酶(ALP)活性的抑制率为28%、增殖率受抑制达48.2%,功能与形态改变与自然衰老细胞的改变类似, 认为辐射诱导成骨细胞提前进入衰老状态, 可作为研究延缓成骨细胞衰老药物的一种细胞模型。 |
| 英文摘要: |
| 137Cs γ-rays were used to irradiate cultured osteoblasts in vitro.Degenerative changes in shape, disorders in function and proliferation of osteoblasts were observed.After irradiation with a single dose of 6.0Gy, the activity of owteoblast ALP and the rate of proliferation were inhibited by 28% and 48.2% respectively.The degeneration of osteoblasts exposed to γ-rays was similar to the natural ageing of cells.It is suggested that γ-irradiation may accelerate the ageing process of osteoblasts.This method may be used for establishing the cell model for the research of drugs to delay osteoblast ageing. |
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