| 陈沙力,孟庆勇,刘树铮.低剂量电离辐射诱导小鼠胸腺细胞蛋白的早期表达[J].中华放射医学与防护杂志,1996,16(3):161-163 |
| 低剂量电离辐射诱导小鼠胸腺细胞蛋白的早期表达 |
| Early expression of proteins in murine thymocytes after whole-body irradiation with low-dose X-rays |
| 投稿时间：1995-03-21 修订日期：1995-07-14 |
| DOI： |
| 中文关键词: X射线诱导蛋白 胸腺细胞 双向电泳 |
| 英文关键词:X-irradiation proteins thymocytes electrophoresis |
| 基金项目:国家自然科学基金 |
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| 中文摘要: |
| 采用双向电泳方法检测低剂量X射线全身照射诱导小鼠胸腺细胞核、细胞浆蛋白的早期表达。结果表明75mGyX射线照射后4小时细胞核出现4个新蛋白点；5个增强蛋白点；l个减弱蛋白点。胸腺细胞浆出现3个新蛋白点和3个增强蛋白点。这些早期基因表达产物可能参与细胞增殖、分化中的细胞信息传递过程和基因表达调控。 |
| 英文摘要: |
| Early expression of proteins in nuclear and cytosolic extracts of thymocytes was investigated in mice exposed to lowdose ionizing radiation by means of twodimensional electrophoresis.It was found that there were 4 novel protein spots sprotein spots with increased density and 1 protein spot with reduced density in the nuclear fraction as well as 3 novel protein spots and 3 protein spots with increased density in the cytosolic fraction 4 hr after whole-body irradiation with 75 mGy X-rays.The implications of these early gene expression products are discussed. |
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