| 王献理,苏士杰,尹洪淑,冯乐平,于开君.低剂量辐射对小鼠种植肿瘤及其放疗的影响[J].中华放射医学与防护杂志,1996,16(3):157-160 |
| 低剂量辐射对小鼠种植肿瘤及其放疗的影响 |
| Effects of low-dose ionizing radiation on tumor-bearing mice and on radiotherapy |
| 投稿时间：1995-03-21 修订日期：1995-07-14 |
| DOI： |
| 中文关键词: 低剂量电离辐射 兴奋效应 荷瘤小鼠 肿瘤放疗 |
| 英文关键词:Low-dose ionizing radiation hormesis tumor-besring mice radiotherapy |
| 基金项目:国家自然科学基金 |
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| 中文摘要: |
| 本文作者用低剂量辐射(D1)诱导的兴奋效应, 探讨对小鼠种植肿瘤及其放疗的影响, 结果证明：D1可降低种植肿瘤细胞的成瘤率(P<0.05),并抑制其生长速度(P<0.05);荷瘤鼠局部放疗预先给予D1,可提高放疗效果；并进一步证明：上述改变可能与D1提高了淋巴细胞自发增殖能力, 降低电离辐射诱发自由基, 提高抗氧化酶活性和增加DNA修复能力有关。 |
| 英文摘要: |
| We studied the effects of low-dose radiation on tumor-bearing mice and on radiotherapy from hormesis induced by low-dose radiation.The results show that D1 can reduce the tumor rate in mice implanted with tumor cells(P<0.05), and inhibit the tumor growth speed(P<0.05);the effects of radiotherapy on tumor-bearing mice can be enhanced by low-dose radiation.It is further demonstrated that these results are concerned with enhancement of lymphocyte spontaneous proliferation, activity of anti-oxidase, ability of DNA to restore and reduce free radical injury.The above results provide an experimental basis for increasing the efficacy of clinical tumor therapy and alleviating side-effects of radiotherapy. |
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