中华放射医学与防护杂志

魏道严,金敖兴,汪思应,等.小剂量X射线全身照射提高小鼠抗瘤能力的整体和离体研究[J].中华放射医学与防护杂志,1996,16(3):151-153.Wei Daoyan,Jing Aoxing,Wang Siying,et al.Augmentation of antitumor effects in mice by low dose X-ray whole body irradiation :in toto and in vitro studies[J].Chin J Radiol Med Prot,1996,16(3):151-153

小剂量X射线全身照射提高小鼠抗瘤能力的整体和离体研究

Augmentation of antitumor effects in mice by low dose X-ray whole body irradiation :in toto and in vitro studies

投稿时间：1995-03-21 修订日期：1995-07-14

DOI：

中文关键词: 小剂量辐射 B₁₆黑色素瘤 Lewis肺癌肿瘤转移

英文关键词:Low dose radiation B₁₆ melanoma Lewis lung carcinoma(LLC) tumor metastases

基金项目:国家自然科学基金

作者	单位
魏道严	230032 合肥, 安徽医科大学核医学教研室
金敖兴	230032 合肥, 安徽医科大学核医学教研室
汪思应	230032 合肥, 安徽医科大学核医学教研室
黄帼	230032 合肥, 安徽医科大学核医学教研室
左祥生	安徽医科大学一附院

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全文下载次数: 2005

中文摘要:

本文作者利用肿瘤血道转移和自发转移模型, 从整体和离体两方面观察75mGyX射线全身照射对小鼠抗瘤能力的影响。结果发现：①与假照组相比, 照射组小鼠B16黑色素瘤血道肺转移结节数明显降低(P<0.01);过继转移至同系小鼠体内的脾细胞, 可明显抑制Lewis肺癌(LLC)的局部生长和自发肺转移(P<0.05～0.01).②与假照组相比, 体外检测照射组小鼠脾细胞对ConAIL-2反应性增强(P<0.01),NK活性明显提高(P<0.01);体内检测其巨噬细胞功能也显着增强(P<0.01),125IUdR标记黑色素瘤细胞在肺内的存留率显着降低(P<0.01).上述结果提示, 小剂量辐射可明显提高小鼠的抗瘤能力；机体免疫功能的增强可能是其抗肿瘤效应的主要机理之一。

英文摘要:

By using the models of hematogenous and spontaneous tumor metastases, the influence of 75mGy X-ray whole-body irradiation on antitumor ability of mice was investigated in toto and in vitro.The results were as follows:(1)As compared with unirradiated control mice, the number of hematogenous pulmonary metastatic colonies of B16 melanoma decreased obviously(P<0.01) in 75mGy X-ray irradiated mice;the splenocytes of the irradiated mice adoptively transferred to syngeneic mice significantly inhibited Lewis lung carcinoma(LLC) growth and spontaneous pulmonary metastasis(P<0.05～0.01).(2) Comparing with those of unirradiated control mice, the in vitro response of NK cytotoxity of the splenocytesfrom irradiated mice to ConA and IL-2 increased greatly, the macrophage function was higher and the retention of ¹²⁵ IUdR-labeled B16 melanoma cells in lungs was lower for the irradiated mice tested in vivo(P<0.01).Our results indicate that low dose radiation can augment murine antitumor ability;the enhancement of immunofunctions may be one of the main reasons for its antitumor effects.

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