刘庆伦,李端,蔡体育.硒对鼻咽癌患者放射治疗后细胞免疫功能的影响[J].中华放射医学与防护杂志,1996,16(2):112-115.Liu Qinglun,Li Duan.Effect of selenium on cell-mediated immunity in patients with nasopharyngeal carcinoma after radiotherapy[J].Chin J Radiol Med Prot,1996,16(2):112-115
硒对鼻咽癌患者放射治疗后细胞免疫功能的影响
Effect of selenium on cell-mediated immunity in patients with nasopharyngeal carcinoma after radiotherapy
投稿时间:1994-11-28  修订日期:1995-05-26
DOI:
中文关键词:    鼻咽癌  淋巴细胞转化  自然杀伤细胞
英文关键词:Selenium  nasopharyngeal carcinoma  lymphocyte transformation  NK cells
基金项目:
作者单位
刘庆伦 510060 广州, 中山医科大学肿瘤研究所 
李端 510060 广州, 中山医科大学肿瘤研究所 
蔡体育 510060 广州, 中山医科大学肿瘤研究所 
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全文下载次数: 1911
中文摘要:
      本文作者报道了硒对鼻咽癌患者放疗后细胞免疫功能影响的体外实验, 结果表明:适宜浓度的硒(4.34×10-7mol/L)显着提高患者经PHA诱导的淋巴细胞转化作用:3H-TdR掺入量由(3.17±2.42)×104·min-1·10-6淋巴细胞增至(5.67±5.63)×104·min-1·10-6淋巴细胞, 较对照组提高了(78.86±77.60)%,P<0.01.同时, 硒还显着提高NK细胞杀伤活性:3H-TdR释放率由(27.90±9.22)%增加至(34.56±13.45)%,P<0.05,提示:硒在恢复放疗后鼻咽癌患者的免疫功能的治疗中, 可能具有一定的价值。
英文摘要:
      in this article the in vitro effect of selenium on T lymphocyte transformation and NK cell activity in patients with nasopharyngeal carcinoma(NPC)after radiotherapy is reported.The results showed that sodium selenite(4.34×10-7 mol/L)significantly enhanced the lymphocyte transformation in response to PHA; the uptake of 3HTdR increased by 78. 98±77. 60% as compared with that of controls(P<0.001).And in the presence of sodium selenite at that concentration,the NK cell activity increased markedly : the specific cytotoxic release of 3H- TdR increased from 27.90 ±9.22% to 34. 56±13.45%(P<0.05).It is suggested that selenium may be valuable in immunothetapy for NPC patients after radiotherapy.
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