| 朱茂祥,龚诒芬,葛桂秀,等.大鼠肺吞噬细胞释放自由基在放射性肺炎发展中的作用[J].中华放射医学与防护杂志,1996,16(2):96-99.Zhu Maoxiang,Gong Yifen,Ge Guixiu,et al.Effect of free radicals released from pulmonary alveolar phagocytes on development of radiation pneumonia in rats[J].Chin J Radiol Med Prot,1996,16(2):96-99 |
| 大鼠肺吞噬细胞释放自由基在放射性肺炎发展中的作用 |
| Effect of free radicals released from pulmonary alveolar phagocytes on development of radiation pneumonia in rats |
| 投稿时间：1994-09-05 修订日期：1995-03-13 |
| DOI： |
| 中文关键词: 肺吞噬细胞 自由基 羟脯氨酸 化学发光 硒 |
| 英文关键词:Pulmonary alveoli phagocytes free radicals hydoxylproline chemiluminescence selenium. |
| 基金项目:解放军总后勤部八五攻关课题 |
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| 中文摘要: |
| 60Coγ射线(20Gy)照射大鼠胸部, 以支气管-肺泡冲洗液细胞(BALFC)的化学发光作为吞噬细胞释放自由基的指标, 用肺组织羟脯氨酸含量评价肺纤维细胞增殖程度, 观察照后0.5,1和2个月时肺吞噬细胞释放自由基的变化及其与肺组织纤维细胞增殖性病变的可能关联。 |
| 英文摘要: |
| Measuring the hydroxylproline(HyP) content in rat lungs and the chemiluminescence(CL) of bronchus alveolar lavage fluid cell (BALFC) at 0.5,1 and 2 months after irradiation with 60Co γ-rays respectively, we found that the amount of BALFC and its CL stimulated by zymosan and the pulmonary HyP content were apparently increased after irradiation,and these alternations took a favourable turn when selenium was supplemented to irradiated rats,suggesting that selenium protected the rats from radiation injury of lung. In addition,we found that there were certain interrelations between the multiplication of pulmonary fibrocytes and the free radicals released from accumulated BALFC in pulmonary alveoli,indicating that the free radicals produced from alveolar phagocytes may be an important factor in development of rat radiation pneumonia. |
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