中华放射医学与防护杂志

李敏,肖家思,阎淑枝,等.放射损伤、烧伤和放烧复合伤早期心室乳头肌细胞内K⁺浓度及动作电位的变化[J].中华放射医学与防护杂志,1996,16(2):85-87.Li Min,Xiao Jiasi,Yan Shuzi,et al.Changes in intracellular K⁺ concentration and action potential of myocardiocytes in early stage of radiation, burn and combined radiation-burn injuries in rats[J].Chin J Radiol Med Prot,1996,16(2):85-87

放射损伤、烧伤和放烧复合伤早期心室乳头肌细胞内K⁺浓度及动作电位的变化

Changes in intracellular K⁺ concentration and action potential of myocardiocytes in early stage of radiation, burn and combined radiation-burn injuries in rats

投稿时间：1994-11-02 修订日期：1995-04-24

DOI：

中文关键词: 放射损伤烧伤放烧复合伤心肌动作电位细胞内K⁺浓度大鼠

英文关键词:Radiation burn combined radiation-burn injury action potential intracellular potassium concentration myocardium rats

基金项目:

作者	单位
李敏	630038 重庆, 重庆第三军医大学生理教研室
肖家思	630038 重庆, 重庆第三军医大学生理教研室
阎淑枝	630038 重庆, 重庆第三军医大学生理教研室
万子兵	630038 重庆, 重庆第三军医大学生理教研室

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中文摘要:

采用K⁺选择微电极(K⁺-ISME)和普通电极, 测定正常大鼠及大鼠放射损伤、烧伤和放烧复合伤后第1,3,8和24小时心室乳头肌细胞内K⁺浓度([K⁺]_i)及跨膜电位的变化。

英文摘要:

in this experiment K⁺-ISME and microelectrode were used respectively to measure the [K⁺]_i concentration and action potential in ventricular papillary myocardiocytes of 92 Wistar rats, which were divided into four groups: normal rats (group C).and rats receiving radiation (group R). burn (group B) and combined radiationburn (group RB), and undergoing measurement 1, 3,8 and 24 hours after respective treatment. It was found that (1) [K⁺]_i was reduced in groups B and RB (especially in group B), but there was no change in group R; (2) RP, APA and V_max were all decreased in three injured groups;(3) APD₅₀ and APD₉₀ were shortened obviously in group B, but were prolonged in both groups R and RB (especially in group R). These results suggest that (1) radiation injury diminishes Na⁺ inflow and K⁺ outflow;(2) burn diminishes Na⁺ inflow and accelerates K⁺ outflow; (3) combined radiation-burn injury is not a simple addition of radiation and burn effects.

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