| 徐辉,陈宗荣.放烧复合伤大鼠心肌细胞膜β-肾上腺素能受体密度变化的实验研究[J].中华放射医学与防护杂志,1996,16(2):81-84.Xu Hui.Changes ofβ-adrenoceptor concentration in myocardial membrane of rats subjected to combined radiation-burn injury[J].Chin J Radiol Med Prot,1996,16(2):81-84 |
| 放烧复合伤大鼠心肌细胞膜β-肾上腺素能受体密度变化的实验研究 |
| Changes ofβ-adrenoceptor concentration in myocardial membrane of rats subjected to combined radiation-burn injury |
| 投稿时间：1994-11-24 修订日期：1994-11-06 |
| DOI： |
| 中文关键词: 放射损伤 烧伤 放烧复合伤 β－肾上腺素能受体 心肌细胞膜 |
| 英文关键词:Radiation injury thermal burns combined radiation-burn injury β-adrenoceptors myocardial membrane |
| 基金项目:国家“八五”攻关课题 |
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| 中文摘要: |
| 采用60Coγ射线全身照射6Gy的大鼠和光烧伤背部皮肤30% TBSA Ⅲ度模型, 动态地观察了放射损伤、烧伤及放烧复合伤大鼠心肌细胞膜β-肾上腺素能受体(βAR)密度在伤后1,3,8,16和24小时的变化情况。结果表明, 放射损伤、烧伤和放烧复合伤后心肌细胞膜βAR的最大结合容量(Bmax)在伤后所观察的5个时相点皆有明显的下降。 |
| 英文摘要: |
| Rats were divided into three groups and subjected to total body irradiation of 6 Gy γ-rays from a 60Co source, 30% total body surface area full tfickness burns,or both of them,respectively. The changes of β-adrenoceptor. concentration in myocardial membrane were observed on 1, 3.8, 16 and 24h after injury.It was found that Bmax was significantly decreased in all the three groups during 24h after injury. The value of KD increased only at 1h and 3h after radiation injury. The decrease of β-adrenoceptor concentration in rats may be one of the major reasons for cardiac dysfunction after radiation, burn and combined injuries, The reasons of decreasing β-adrenoceptor concentration are discussed. |
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