| 杜泽吉,苏燎原,孔向蓉,等.低剂量γ射线诱导的淋巴细胞DNA断裂的适应性反应[J].中华放射医学与防护杂志,1996,16(1):32-34.Du Zeji,Su Liaoyuan,Kong Xiangrong,et al.Adaptive response of DNA strand breaks in lymphocytes to low dose and γ-rays[J].Chin J Radiol Med Prot,1996,16(1):32-34 |
| 低剂量γ射线诱导的淋巴细胞DNA断裂的适应性反应 |
| Adaptive response of DNA strand breaks in lymphocytes to low dose and γ-rays |
| 投稿时间：1994-09-10 修订日期：1995-02-23 |
| DOI： |
| 中文关键词: 低剂量γ射线 淋巴细胞 DNA断裂 适应性反应 |
| 英文关键词:Low dose γ-rays lymphocytes DNA strand breaks adaptive response |
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| 中文摘要: |
| 利用DNA解旋荧光测定法(FADU)研究了低剂量γ射线诱导的淋巴细胞DNA断裂的适应性反应, 并观察了不同浓度的3-氨基苯甲酰胺(3-AB)对适应性反应的影响。结果表明：0.5～4.0cGyγ射线照射(D1), 均可诱导淋巴细胞对15Gyγ射线照射的抗性, 8.0cGy引起的适应性反应不明显, 2.0, 4.0cGy的γ射线为诱导适应性反应的最适剂量。5～20Gy的D2照射均可显现出D1(2.0cGy)诱导的适应性反应, 以15Gy照射后适应性反应最强。0.5mmol/L的3-AB就可明显地抑制适应性反应。当浓度增至5.0mmol/L时, 适应性反应几乎完全受抑。 |
| 英文摘要: |
| Fluorometric analysis of DNA unwinding was used to study the adaptive response of DNA strand breaks induced by low dose γ-rays and the effect of pADPRT inhibitor-3-AB on the adaptive response.The results indicated that 0.5-4 cGy γ-rays could induce adaptive response of DNA strand breaks in lymphocytes, especially at the doses of 2.0 and 4.0 cGy.This response was not obvious after 8.0 cGy γ-rays irradiation.A challenge dose of 5-20 Gy could make the response expressed, 15 Gy was the best one and 30 Gy was too high to give an adaptive response.0.5 mM 3-AB could inhibit the response vigorously.As the concentration increased, the adaptive reaponse could be inhibited completely. |
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