| 罗成基,郭朝华,周燕虹,等.白细胞介素-3对放烧复合伤小鼠造血功能的影响[J].中华放射医学与防护杂志,1996,16(1):28-31.Luo Chengji,Guo Chaohua,Zhou Yanhong,et al.Effects of interleukin-3 on hemopoietic function after combined radiation-burn injury in mice[J].Chin J Radiol Med Prot,1996,16(1):28-31 |
| 白细胞介素-3对放烧复合伤小鼠造血功能的影响 |
| Effects of interleukin-3 on hemopoietic function after combined radiation-burn injury in mice |
| 投稿时间：1994-11-24 修订日期：1995-04-05 |
| DOI： |
| 中文关键词: 白细胞介素－3 放烧复合伤 造血功能 |
| 英文关键词:Interleukin-3 combined radiation-burn injury hematopoietic function |
| 基金项目:国家自然科学基金 |
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| 中文摘要: |
| 作者研究了IL-3对放烧复合伤动物骨髓造血功能的影响。发现3T3-IL-3细胞培养上清液中含有很高活性的IL-3.用它给放射损伤或放烧复合伤动物预防加治疗应用, 对造血的刺激作用显着优于单独预防或单独治疗。对造血的这种良好作用既表现在造血实质细胞, 也表现在造血基质细胞；在实质细胞中粒系祖细胞、红系早期和晚期祖细胞都有作用。IL-3对造血功能未表现抑制的烧伤动物未显示出对造血的刺激作用。 |
| 英文摘要: |
| Destruction of hemopoietic function is one of the most basic pathologic changes in combined radiation-burn injury.Interleukin-3 exhibits a broad-spectum stimulating effect on proliferation and differentiation for hemopoietic cells.This study was aimed to investigate the effects of interleukin-3 on hmopoietic function after combined radiation-burn injury in mice.The results show that preventing and additionally treating radiation injury or the combined radiation-burn injury with IL-3 have better effects on the stimulation of hematopoiesis in vivo than only preventing or treating with IL-3.This favourable stimulation of hemopoiesis was not only expressed in granulocyte-macrrophage progentors(CFU-GM) or erythroid progenitors(CFU-E, BFU-E), but also in bone marrow stromal elements(CFU-F).Stimulating effect on hemopoiesis was not shown in animals with burn injury in which hemopoietic failures did not appear.The results indicate that excellent prospects are expected by using IL-3 in treating radiation injury or combined radiation-burn injury. |
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