| 赵坡,杨志祥,李国民,高亚兵,王德文.人放射性皮肤溃疡c-erbB-2、EGFR蛋白高表达病理研究[J].中华放射医学与防护杂志,1996,16(1):26-27 |
| 人放射性皮肤溃疡c-erbB-2、EGFR蛋白高表达病理研究 |
| A pathological study on overexpression of c-erbB-2,EGFR proteins in human radiation skin ulcer |
| 投稿时间：1995-02-11 修订日期：1995-04-06 |
| DOI： |
| 中文关键词: 放射性皮肤溃疡 癌基因 生长因子受体 |
| 英文关键词:Radiation skin ulcer oncogene epidermal growth factor receptor |
| 基金项目:国家自然科学基金;中国博士后科学基金 |
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| 摘要点击次数: 2289 |
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| 中文摘要: |
| 我们应用c-erbB-2、EGFR蛋白抗体和微波炉抗原修复法对25例人放射性皮肤溃疡进行免疫组织化学研究。结果发现c-erbB-2癌蛋白高表达阳性率为92.0%(23/25), EGFR蛋白高表达阳性率为73.7%(14/19);二者阳性部位一致, 主要见于鳞状上皮细胞膜、间质纤维母细胞、血管内皮细胞以及小动脉中层平滑肌细胞和外层纤维细胞胞质, 提示c-erbB-2、EGFR蛋白的高表达可能与放射性皮肤溃疡的癌变和难以愈合有关。 |
| 英文摘要: |
| We performed an immunohistochemical study in 25 cases of human radiation skin ulcer by using c-erbB-2, Epidermal growth factor receptor(EGFR), protein antibodies and repairing method of antigen with microwave oven.The results show that the positive rate for overexpression of c-erbB-2 oncoprotein was 92.0% (23/25), and EGFR was 73.7% (14/19).The positive position for overexpression of c-crbB-2 was mainly observed on cell memberane of squamous epithelial cells and cell plasma of fibroblasts, endotheliocytes, and leiomyocytes in media and fibrocytes in adventitia of the arterioles in mesenchyme.It is suggested that the overexpression of c-erbB-2 and EGFR proteins might be related to cancer transformation and poor healing in radiation skin ulcers. |
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