| 陈宪,横田 启,大津留 健,木水 洁,利波久雄,山本 达.放射性肝损伤31P-磁共振波谱分析研究[J].中华放射医学与防护杂志,1996,16(1):21-25 |
| 放射性肝损伤31P-磁共振波谱分析研究 |
| In vivo 31P-magnetic resonance spectroscopic studies of radiation hepatitis |
| 投稿时间：1994-10-07 修订日期：1995-07-17 |
| DOI： |
| 中文关键词: 31P-磁共振波谱分析 放射性肝损伤 |
| 英文关键词:31P-magnetic resonance spectroscopy radiation hepatitis |
| 基金项目: |
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| 中文摘要: |
| 对金仓鼠肝区作8MeV电子束40Gy一次照射, 分别对照射后1, 2, 3天, 1, 4, 8周和9个月的活体动物肝脏置6.34T磁场强度的波谱仪作31P-磁共振波谱分析, 然后摘出动物肝脏作组织学对照研究。结果表明：以β-ATP信号强度为基准计算的各峰值信号强度比中, 照射后1～3天的PME增高, 照射后1周以上的各组γ-ATP和α-ATP均示降低；细胞内pH示照射后1天升高, 2和3天随之降低, 照后1～4周再度升高后与前者有显着性差异(P<0.05).组织学图像示肝细胞点状坏死, 肝细胞脂肪变性, 肝细胞萎缩等。作者认为：31P-磁共振波谱分析对放射性肝损伤的肝能量代谢测定是准确和有价值的。 |
| 英文摘要: |
| Thirty-five Syrian golden hamsters were divided into 7 groups based on the time interval following irradiation (B to H).Group A served as the control and groups B to H were designated as one day, 2 days, 3 days, 1 week, 4 weeks, 8 weeks and 9 months after irradiation, respectively.The hamster liver received a single 40 Gy dose of radiation using an 8 MeV electron beam.A magnetic field of 6.34 Tesla and 31P-resonance frequency appropriate for the spectrometer.All hamsters were sacrificed and histological specimens were obtained.The ratios of each peak value phosphourus signal to β-ATP obtained from the control group and irradiated groups showed that the peak intensities of the PME was higher in groups B-D, γ-ATP and α-ATP in groups of later than 1 week after irradiation were lower than those of the control group.Intracellular pH value for group B was higher than that for group A,and pH values for groups C and D were lower at once, while pH values for groups E and F were higher again than those for C and D(P<0.05).Histological specimens showed focal lose of hepatocytes, fatty degeneration and hepatocyte atrophy.The authors consider that 31P-MRS is very useful in evaluation of the metabolic changes in radiation hepatitis. |
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