中华放射医学与防护杂志

万虹,龚守良,刘树铮.低剂量电离辐射诱导小鼠脑c-fos原癌基因的表达[J].中华放射医学与防护杂志,1996,16(1):15-17.Wan Hong,Gong Shouliang.Expression of c-fos protooncogene in mouse brain following low dose irradiation[J].Chin J Radiol Med Prot,1996,16(1):15-17

低剂量电离辐射诱导小鼠脑c-fos原癌基因的表达

Expression of c-fos protooncogene in mouse brain following low dose irradiation

投稿时间：1995-05-15 修订日期：1995-06-30

DOI：

中文关键词: 低剂量照射原癌基因原位杂交

英文关键词:Low dose radiation protooncogene in situ hybridization

基金项目:国家自然科学基金

作者	单位
万虹	130021 长春, 白求恩医科大学卫生部放射生物重点实验室
龚守良	130021 长春, 白求恩医科大学卫生部放射生物重点实验室
刘树铮	130021 长春, 白求恩医科大学卫生部放射生物重点实验室

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中文摘要:

应用原位杂交方法观察75mGy全身照射后不同时间小鼠脑神经元c-fos原癌基因mRNA水平的变化。结果发现, 75mGy全身照射可诱导小鼠脑内广泛神经元c-fos的表达, 大脑皮质和下丘脑尤为明显。照射后15分钟c-fosmRNA即出现, 1小时最为明显, 2小时后逐渐减少, 8小时完全消失。提示低剂量辐射可增加神经元的活性。

英文摘要:

In situ hybridization was used to examine the expression of c-fos mRNA in mouse brain following whole body irradiation(WBI) with 75 mGy X-rays.The results showed that WBI with 75 mGy could stimulate the expression of c-fos in extensive areas of neurons in the mouse brain, especially in the cerebral cortex and hypothalamus.The c-fos mRNA appeared 15 min after irradiation, reached its peak within 1 h and began to fade at 2 h with its total disappearance 8 h after irradiation.These findings indicate that low dose radiation can enhance the activity of the neurons in certain areas of the brain.

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