| 金玉珂,王献理,王明东,孙淑清,王彬,薛蕙.电离辐射致生殖细胞染色体畸变与显性致死及其生物学意义[J].中华放射医学与防护杂志,1995,15(6):400-403 |
| 电离辐射致生殖细胞染色体畸变与显性致死及其生物学意义 |
| Radiation-induced chromosome aberrations and dominant lethality of germ cells and their biological significance |
| 投稿时间：1995-01-05 修订日期：1995-03-31 |
| DOI： |
| 中文关键词: 生殖细胞 染色体畸变 显性致死突变 电离辐射 小鼠 |
| 英文关键词:Chromosome aberrations germ cells mice dominant lethality ionizing radiation |
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| 中文摘要: |
| 在不同照射条件下观察雄性小鼠生殖细胞染色体畸变率及显性致死突变率。证明染色体畸变是诱发显性致死的重要原因,照后不同时期受精对染色体畸变和显性致死有很显着影响,从而提示不同照射人群遗传危害差异的原因。 |
| 英文摘要: |
| The chromosome aberration rates and dominant lethality of germ cells in male mice at different interval times after acute and chronic radiations were investigated.The acute irradiation was carried out with X-rays at dose rates and doses of 0.05Gy/min, 0-1.OGy and 0.44Gy/min 2.OGy,respectively.The chronic irradiation was performed with 60Coγ-rays at dose rate and cummulated dose of 4.17 × 10-5Gy/min and 0-2.1Gy, respectively.The results indicated that the dominant lethality was induced through chromosome aberrations of germ cells.The time of fertilization after irradiation influenced prominently on the chromosome aberration rates and dominant lethality.In the acute exposure group,fertilization time was 140 days after irradiation with 2.OGy,and the spermatogonia were mainly injured.The dominant lethality was 9.23% for the irradiated and 5.73% for the blank controls (P>0.05).In the chronic exposure group,the fertilization time was 24 days after irradiation with 2.1Gy.and the primary spermatocytes were mainly injured;the dominant lethality was 16.3% for the irradiated and 5.83% for the blank controls (P<0.05).These findings suggest that persons receiving acute radiation exposure from nuclear explosion or radiation accident may develop genetic harm while those subjected to occupational chronic radiation exposure may not. |
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