| 陈英,武藤正弘,久保ゑい子,松田洋一.辐射诱发胸腺淋巴瘤中包含易位的染色体畸变[J].中华放射医学与防护杂志,1995,15(6):396-399 |
| 辐射诱发胸腺淋巴瘤中包含易位的染色体畸变 |
| Analysis of initial events in radiation-induced lymphomagenesis:investigation of chromosome aberrations including translocations |
| 投稿时间：1994-04-27 修订日期：1995-03-13 |
| DOI： |
| 中文关键词: 辐射 胸腺淋巴瘤 染色体畸变 |
| 英文关键词:Radiation thymic lymphoma chromosome aberrations |
| 基金项目: |
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| 中文摘要: |
| 为了研究包含易位的染色体畸变在辐射诱发淋巴瘤过程中的作用,作者分析了供体型T淋巴瘤细胞的染色体G带核型。结果观察到,在供体派生的T细胞淋巴瘤中,有许多数目和结构畸变。有意义的是：几乎在每组淋巴瘤中都发现了含有易位的共同畸变。如：D组中11号和12号染色体的易位；E组中12号和15号染色体的易位；F组中7号和10号染色体的易位；G组中1号和13号染色体的易位；H组中6号和X染色体的易位；A组和F组中还有共同的15号染色体三体。这些结果表明：包含易位的染色体畸变在辐射诱发淋巴瘤过程中可能是重要的启动事件。畸变细胞数/总细胞数图6小鼠每条染色体的畸变频率常发生畸变的染色体,畸变类型包括三体和易位,在34个淋巴瘤中发生频率为53%.其次12号染色体的易位发生率为32%.而1号、13号和X染色体也有20%左右的畸变率。与此相反,2,3,4,8,9,14,16,17和19号染色体几乎未检出畸变。一般认为,肿瘤的发生过程与原癌基因的激活或抑癌基因的失活有关。在淋巴瘤形成的原发事件中,染色体的某些部位可能含有原癌基因的起动子或操纵子。这些基因片断被射线打断并发生错误重接(表现为染色体的易位),从而启动了肿瘤的多阶段过程。 |
| 英文摘要: |
| To investigate the contribution of chromosome aberrations in radiation- induced lymphomagenesis, chromosome G-banding analysis of the lymphoma cells(8 groups and 34 kinds of cells),of which each group was derived from a single donor by intrathymic injection of a limited number of prelymphoma cells, was performed.Many numerical and structural aberrations were observed in the donor-derived T cell lymphomas. Common aberrations including translocations were found almost in the lymphomas of all groups.Translocations between chromosomes 11 and 12,12 and 15,7 and 10,1 and 13, 6 and X were found in D, E, F, G,H groups,respectively.There were also common aberrations such as trisomy 15 in A and F groups.These results indicate that chromosome aberrations including translocations may be important candidates of initiating events in radiation-induced lymphomagenesis. |
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