| 白蕴红,王德文,徐在海,杨怡.纤维连接蛋白和层粘连蛋白在大鼠放射性肺损伤中的变化[J].中华放射医学与防护杂志,1995,15(5):330-333 |
| 纤维连接蛋白和层粘连蛋白在大鼠放射性肺损伤中的变化 |
| Changes of fibronectin and laminin in radiation pulmonary injury of rats |
| 投稿时间：1994-08-23 修订日期：1995-03-24 |
| DOI： |
| 中文关键词: 纤维连接蛋白 层粘连蛋白 大鼠 肺 照射 |
| 英文关键词:fibronectin laminin rats lungs irradiation |
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| 中文摘要: |
| 用光镜、电镜及免疫组化方法,动态观察了大鼠经胸部照射30Gy后肺组织内纤维连接蛋白(FN)和层粘连蛋白(LN)的变化。结果显示,照射组大鼠肺组织内FN、LN分布紊乱,FN含量在病变早期较明显增多,而病变后期则逐渐减少；LN在各期均有不同程度增加。提示,FN主要参与放射性肺损伤早期病变的发生发展；LN参与肺损伤病变的全过程。 |
| 英文摘要: |
| The changes of fibronectin (FN)and laminin (LN) in the rat lungs irradiated locally with 30Gy were observed by light microscopy, electronmicroscopy and immunohistochemistry . The results indicated that distribution of FN and LN in the irradiated lungs was random, the content of FN apparently increased in early phase and gradually decreased in late phase, and the content of LN increased all the way in various degrees.The results suggest that FN is mainly related to the generation and development of early pathological changes in radiation pulmonary injury, whereas LN is related to its entire process . |
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