| 孟庆勇,姜杰,蔡露,金玉珂.Ⅱ 化学物质与电离辐射之间的交叉适应性反应[J].中华放射医学与防护杂志,1995,15(5):298-301 |
| Ⅱ 化学物质与电离辐射之间的交叉适应性反应 |
| ⅡCross-resistance to ionizing radiation and to chemical mutagens |
| 投稿时间：1994-10-18 修订日期：1995-04-08 |
| DOI： |
| 中文关键词: 交叉适应性反应 低浓度化学物质 低剂量辐射 |
| 英文关键词:Adaptive response chemical mutagens ionizing radiation Mice germ cells |
| 基金项目:国家自然科学基金 |
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| 摘要点击次数: 2568 |
| 全文下载次数: 1419 |
| 中文摘要: |
| 本文作者利用小鼠生殖细胞对低剂量辐射(50mGy)X射线和低浓度化学物质(MMC,H2O2,CP)之间的交叉耐受性作了研究。首次证明在整体条件下的生殖细胞中,无明显毒性剂量的MMC(0.1和0.5mg/kg)和H2O2(0.02和0.05mol/L)均可诱导抗1.5GyX射线诱发的生殖细胞染色体损伤；并且50mGy射线也可诱导抗大剂量MMC(3.0和5.0mg/kg)和H2O2(0.5和1.0mol/L)诱发的生殖细胞染色体损伤。与此相反,低浓度的烷化剂环磷酰胺(0.5和1.0mg/kg)不能诱导抗电离辐射诱发生殖细胞染色体损伤的适应性反应；低剂量辐射也不能诱导抗大剂量环磷酰胺(25和40mg/kg)的适应性反应,这些结果说明：辐射与DNA交联剂和DNA氧化性损伤因子之间存在着广泛低剂量诱导相互耐受性的适应性反应,而与产生DNA烷基化损伤的烷化剂之间不存在着交叉抗性。 |
| 英文摘要: |
| In this study, the cross-adaptive response to radiation and to chemical mutagens (mitomycin C, H2O2 ,cyclophosphamide)was observed in vivo in mouse germ cells. The results showed that low concentration of mitomycin C (0.1, 0.5mg/kg) and H2O2, (0.02, 0.05 mol/L) could reduce the frequency of chromosome aberration in mouse germ cells in vivo caused by subsequent irradiation (1.5 Gy X-rays);and 50 mGy X-rays also made the cells have a resistance to chromosome damage by high concentration mitomycin C (3.0, 5.0 mg/kg) and H2O2 (0.5 and 1.5 mol/L) .Contrary to those mentioned above, low concentration of cyclophosphamide (0.5, 1.0 mg/kg)made the germ cells more susceptible to induction of chromosome aberration by ionizing radiation, and at the same time,low dose radiation also made the cells more susceptible to the chromosome damage by high concentration cyclophosphamide (25, 40 mg/kg) .These results indicate that there is a cross-resistance to ionizing radiation and to DNA cross-linking agents (mitomycin C) and DNA oxidizing agents (H2O2) , but there is no cross-resistance to radiation and to alkylating agents (cyclophosphamide ).All these results provide some important materials for elucidating the mechanism of the adaptive response induced by ionizing radiation. |
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