| 吕玉民,傅宝华,陈玉浩,赵凤玲,刘金荣,任春仙.两例事故受照者精子和淋巴细胞染色体畸变类型的比较[J].中华放射医学与防护杂志,1995,15(3):178-181 |
| 两例事故受照者精子和淋巴细胞染色体畸变类型的比较 |
| Comparison of chromosome aberration type in lymphocytes and sperm in two cases exposed to accidental radiation |
| 投稿时间：1994-04-20 修订日期：1994-08-05 |
| DOI： |
| 中文关键词: 60Co辐射事故 人精子 淋巴细胞 染色体结构畸变类型 |
| 英文关键词:60Co radiation accident human spermatozoa lymphocytes structural chromosome aberrations |
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| 中文摘要: |
| 本文作者对两例在60Co辐射事故中全身受到大剂量γ线照射的急性放射病患者受照6(7)年后的精子和淋巴细胞染色体结构畸变类型进行了分析。两患者精子染色体是以断裂型畸变为主,断裂型畸变是重接型的2倍；淋巴细胞以重接型畸变为主,是断裂型的2倍。两类细胞都是以染色体型畸变为主,分别是单体型的5倍和9倍,精子染色体非稳定畸变占结构畸变的40%,明显高于淋巴细胞(19%),而稳定、半稳定畸变分别占结构畸变的14%和46%,低于淋巴细胞(29%和52%).结果表明：精子和淋巴细胞染色体结构畸变具有不同的特点；精子发生不同时期的生殖细胞和淋巴细胞,可能存在电离辐射所致染色体损伤修复能力的差异。 |
| 英文摘要: |
| The types of structural chromosome abnormalities in human spermatozoa and lymphocytes in two cases exposed to 60Co whole-body six or seven years earlier are analyzed,and the repair mechanism of radiation-induced chromosome lesions are discussed.The frequency of breakage-type is two times higher than that of exchange-type in spermatozoa while the frequency of exchange-type is two times higher than that of breakage-type in lymphocytes.The frequency of chromosome-type aberrations is five times higher than that of chromatid-type aberrations in sperm,and nine times in lymphocytes.The stable,semistable and unstable types account for 14%,46% and 40% of structural abnormalities in spermatozoa,respectively and 29%,52%,19%,in lymphocytes respectively.The results indicate that the types of structural chromosome aberrations in human sperm are different from those in lymphocytes.The repair ability of radiation-induced chromosome lesions in the germ cells at different stages of spermatogenesis and lymphocytes is probably different. |
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