| 汪德清,沈文梅,田亚平,刘国廉,杨素霞,周淑珍,孙仲怡.黄芪总黄酮对γ射线所致V79细胞DNA链断裂损伤防护作用的实验研究[J].中华放射医学与防护杂志,1995,15(2):106-107 |
| 黄芪总黄酮对γ射线所致V79细胞DNA链断裂损伤防护作用的实验研究 |
| Protective effect of total flavonoids of astragalus mongholicus Bunge on ONA strand breaks,in V79 cells caused by γ-rays |
| 投稿时间：1994-05-03 修订日期：1994-08-19 |
| DOI： |
| 中文关键词: γ射线 V79细胞 DNA 黄芪总黄酮 FADU |
| 英文关键词:γ-rays V79 cells DNA flavonoids astragalus mongholicus Bunge fluorometry |
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| 中文摘要: |
| 本文作者用DNA解旋的荧光检测(FADU)方法观察了γ射线对V79细胞DNA的损伤作用及黄芪总黄酮对其作用的防护效果。结果表明细胞DNA链断裂率与γ射线的照射量成正比。黄芪总黄酮浓度为0.6mg/ml时即对DNA损伤有保护作用,当浓度达1.2mg/ml时,对γ射线所致DNA链断裂损伤有非常显着的防护效果。 |
| 英文摘要: |
| In the report DNA strand breaks in V79 cells caused by γ-rays and the protective effect of total flavonoids of astragalus mongholicus Bunge(TFA)have been studied by fluorometric assay of DNA unwinding.The results indicated that the rate of DNA strand break increased with the increase of γ-ray doses.Even When the concentration of TFA was as low as 0.6/ml,it still showed some protective effect on DNA strand breaks.When its concentration was up to l.2mg/ml,TFA could effectively protect DNA from radiation damage. |
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