| 苏旭,张迎春,刘树铮.不同剂量照射对胸腺细胞四个亚组的影响[J].中华放射医学与防护杂志,1995,15(2):103-105 |
| 不同剂量照射对胸腺细胞四个亚组的影响 |
| Effects on subsets of thymic lymphocytes after X-irradiation with different doses |
| 投稿时间：1994-04-27 修订日期：1994-07-19 |
| DOI： |
| 中文关键词: 电离镭射 胸腺细胞亚组 流式细胞术(FCM) |
| 英文关键词:Gamma radiation T subsets flow cytometry |
| 基金项目: |
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| 中文摘要: |
| 本实验采用双荧光流式细胞术研究了不同剂量x射线照射后24小时,昆明小鼠胸腺T细胞四个亚组的变化,结果表明：各亚组对辐射的敏感性有较大的差异。其辐射敏感性依次为CD4+CD8+CD4-CD8-CD4-CD8+CD4+CD8-,由于各亚组辐射敏感性的差异,导致了大剂量照射后各亚组之间比例的改变。 |
| 英文摘要: |
| Kunming Mice were whole-body irradiated with 0.5,1.0,2.0and 4.0 Gy X-rays.The thymic lymphocytes were analyzed by flow cytometry with fluorecscent monoclonal antibodies 24 hours after irradiation.It was found that the percentages of CD4+CD8-,GD4-CD8+ and CD4-CD8- cells increased in varying degrees,while the percentage of CD4+CD8+ cells showed a dose -dependent decrease.However,the absolute number of total thymic lymphocytes and the subsets decreased.The absolute number of CD4+CD8+ cells decreased more markedly than that of other subsets.These observations suggest that the radiosensitivity varied in different stages of differentiations of.the thymocytes.The order of radiosensitivity was:CD4+CD8+>CD4-CD8->CD4-CD8+> CD4+CD8-. |
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