| 孙世荃,李爱筠,马如维,李幼忱.非规范案例的辐射致癌病因概率计算──一例钚内污染工人肘部恶性纤维组织细胞瘤的病因判断[J].中华放射医学与防护杂志,1995,15(1):24-28 |
| 非规范案例的辐射致癌病因概率计算──一例钚内污染工人肘部恶性纤维组织细胞瘤的病因判断 |
| Calculation of probability of causation for non-specified radiogenic cancer cases──etiologic judgement of a malignant fibrous histiocytoma developed |
| 投稿时间：1994-05-17 修订日期：1994-07-08 |
| DOI： |
| 中文关键词: 病因概率 钚 肿瘤 病因判断 辐射致癌 |
| 英文关键词:Radiogenic cancers probability of causation plutonium contamination |
| 基金项目: |
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| 摘要点击次数: 2567 |
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| 中文摘要: |
| 结合一例钚内污染人员所患肘部恶性纤维组织细胞瘤的辐射病因判断,提出非规范病例辐射致癌病因概率(PC)计算方法,作为示范。根据肿瘤的组织结构提出三种可能的靶细胞。通过现有剂量监测数据计算三种靶细胞的照射剂量。再利用间接导出的相应的致癌超额相对危险系数计算肿瘤来自所受照射的病因概率。其结果因所选用的靶细胞、危险系数和计算模型而有根大不同,最大相差4个量级。由于这个病例情况比较复杂,因此作者提出的计算步骤可供计算其它非规范病例PC参考。本文作者还结合国内、外钚内污染人员的医学观察经验对钚致癌的可能性进行讨论。 |
| 英文摘要: |
| A criterion for the compensation of patients with radiogenic cancer has been formulated for five specified cancers. A method of calculation of the probability of causation (PC) of non-specified cancers was applied to a case of malignant fibrous histiocytoma developed at the elbow of a plutonium contaminated worker. According to the histologic structure of the tumour, there were three possible target cells, and their doses were evaluated with the available data of urine plutonium. Then PC was calculated with excess relative risk coefficient indirectly deduced from related animal experiment.The result showed that the obtained PC varied greatly with the supposed target cells.If the target cells were periosteum cells,the PC might exceed 50 percent, but that might not be true, and the tumour might come from fibroblasts, and then PC might be less than 1 percent. |
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