| 陶来宝,陈家佩.小鼠血清中的粒系造血活性及其照后改变[J].中华放射医学与防护杂志,1995,15(1):20-23 |
| 小鼠血清中的粒系造血活性及其照后改变 |
| Granulopoietic activity in mouse serum and its changes after irradiation |
| 投稿时间：1994-03-22 修订日期：1994-05-24 |
| DOI： |
| 中文关键词: 粒系刺激活性 粒系抑制活性 照射 刺激因子 CFU－GM产率 |
| 英文关键词:Granulopoietic activity γ-irradiation stimulating factors CFU-GM |
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| 中文摘要: |
| 利用体外半固体琼脂培养骨髓粒单系祖细胞的方法测定小鼠血清中粒系造血活性,经8Gyγ射线照射后4天粒系刺激活性趋于降低；照后7～10天,显示一定程度的升高,为正常血清的140%左右：第14天呈下降趋势。经3,5,7,9Gy不同剂量照射后,血清中的粒系造血活性随照射剂量的增加而增高。9Gy照射组最高,照后第7天可为正常的200%以上,用后12天时小鼠中的粒系造血刺激活性仍高于正常血清。照后小鼠血清中亦同时存在粒系造血抑制活性,照后1天即可以观察到,照后10天前比正常小鼠明显。作者对血清中粒系造血活性升高机理及存在抑制活性对放射病时造血损伤修复的影响进行了探讨。 |
| 英文摘要: |
| Using the method of colony formation of CFU-GM, granulopoietic activity in mouse serum was estimated. The experimental results showed that normal mouse serum was capable of stimulating the growth of CFU-GM. This stimulant activity elevated at 7-10th days after irradiation with 8 Gy γ-rays, and the maximal level was 140% of normal serum. At the 14th day post exposure, the increased stimulant acivity tended to decrease. The changes of stimulant granulopoietic activity was also seen in mice irradiated with 3,5,7,9 Gy γ-rays. The activity rose with the increasing radiation doses and might last to the 12th day after irradiation. Meanwhile, there was increased inhibitory granulopoietic activity in irradiated mouse serum, especially by 10 days post exposure.The significance of the variation of serum stimulant and inhibitory activities after radiation and its importance in the development of hemopoietic injuries caused by radiation are discussed. |
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