| 吕秋军,黄沙菲,周锡鹏,宋家云,唐仲雄.复方紫归对60Co γ射线照射小鼠免疫功能的影响[J].中华放射医学与防护杂志,1995,15(1):17-19 |
| 复方紫归对60Co γ射线照射小鼠免疫功能的影响 |
| Effect of Zi Gui decoction on immune function in 60Co γ-ray irradiated mice |
| 投稿时间：1994-01-04 修订日期：1994-04-21 |
| DOI： |
| 中文关键词: 复方紫归 γ射线照射 T、B淋巴细胞 白细胞介素－1,2 自然杀伤细胞 |
| 英文关键词:Zi Gui decoction γ-ray irradiation T and B lymphocyts proliferation IL-2 IL-2 natural killer cells |
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| 中文摘要: |
| 作者在实验中观察了复方紫归对60Coγ射线照射小鼠免疫功能的影响。结果表明该复方能显着增强受照小鼠刀豆蛋白A及细菌脂多糖诱导的脾细胞增殖反应,促进腹腔巨噬细胞分泌白细胞介素-1及脾细胞分泌白细胞介素-2.提高受照小鼠自然杀伤细胞的活性,揭示本复方可减轻60Coγ射线对小鼠免疫功能的抑制作用。 |
| 英文摘要: |
| Zi Gui decoction(ZG), a complex preparation of traditional Chinese herbal medicine, consists mainly of Radix Angelicae and Radix Astragali. We investigated the effects of ZG on mitogen induced proliferation, IL-1 and -2 production, natural killer(NK) cell activity in 60Co γ-ray irradiated mice.After 5 Gy whole body irradiation, mice were treated i.g. with ZG( 1-2, 1.8g/kg/day) for 20 days. An enhancement in Con A-and LPS-induced proliferations of splenocytes from the two dosage groups were observed. There were marked increses in IL-1 activity in peritoneal macrophage culturesa and IL-2 activity in splenocyte cultures from irradiated mice treated wtih ZG. The two dosage groups also showed significant potentiation of NK cell activity against YAC-1 target cells.The above results indicated that ZG could promote the recovery of immune functions in γ-ray irradiated mice. |
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