中华放射医学与防护杂志

蔡勇,龚曼丽,饶用清.胞浆阻滞微核测试法研究³H－TdR诱导的小剂量适应性反应[J].中华放射医学与防护杂志,1995,15(1):14-16.Cai Yong,Gong Manli,Rao Yongqing.Adaptive response of human lymphocytes to low doses of tritiated thymidine by using cytokinesis-block micronucleus method[J].Chin J Radiol Med Prot,1995,15(1):14-16

胞浆阻滞微核测试法研究³H－TdR诱导的小剂量适应性反应

Adaptive response of human lymphocytes to low doses of tritiated thymidine by using cytokinesis-block micronucleus method

投稿时间：1994-02-18 修订日期：1994-07-28

DOI：

中文关键词: 胞浆阻滞微核测试法 ³H－TdR 适应性反应

英文关键词:³H-TdR cytokinesis-block micronucleus method lymphocytes adaptive response

基金项目:

作者	单位
蔡勇	100034 北京市肿瘤防治研究所放疗科
龚曼丽	100083 北京医科大学放射医学教研室
饶用清	100083 北京医科大学放射医学教研室

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中文摘要:

作者采用胞浆阻滞微核测试法,选用4个健康成年人静脉血,分别以3.7×10²Bq/ml、1.48×10³Bq/ml³H-TdR作为小剂量照射,3.7×10⁴Bq/ml³H-TdR和⁶⁰Coγ射线1.5Gy作为大剂量照射,结果发现先用小剂量照射,再加大剂量照射的微核率比单独大剂量照射微核率低,经统计学检验,观察值和预期值有显着性差异,表明人外周血淋巴细胞微核分析存在着小剂量辐射诱导的适应性反应现象,且个体之间有差异性,同时发现3-氨基苯胺对小剂量诱导的适应性反应有阻断作用。

英文摘要:

In our experiments adaptive response was found by using cytokinesisblock micronucleus method. The experiments were carried out in human lymphocytes from four donors. The cells were previously exposed to low concentrations of ³H-TdR at 3.7×10²Bq/ml and 1.48×10²Bq/ml, and subsequently were challenged with high dose of ³H-TdR(3.7×10⁴Bq/ml) or 1.5Gy of ⁶⁰Co γ-rays. The results showed that low dose exposure could cause adaption and lead to a reduction in the number of micronuclei induced by the challenging dose. It indicated that an adaptive response was observed in human lymphocytes and there were variations among individuals.It was also found that the adaptive response could be eliminated by adding 3-AB.

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