| 周舜元,郭芙蓉,耿秀生.氚水在小鼠体内的代谢[J].中华放射医学与防护杂志,1985,5(1):22-26 |
| 氚水在小鼠体内的代谢 |
| Metabolic Behavior of Tritiated Water in Mice |
| 投稿时间：1983-08-30 |
| DOI： |
| 中文关键词: 氚的代谢 生物半排出期 生物样品测定 放射毒建 |
| 英文关键词:tritium metabolism internal irradiation |
| 基金项目: |
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| 摘要点击次数: 2870 |
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| 中文摘要: |
| 本文利用高氯酸-过氧化氢(HClO4H2O2)消化和液闪计数测定生物样品中氚的方法, 研究亍腹腔注入氚水后65天内氚在小鼠各脏器干、湿组织中的分布与滞留, 并估算了剂量.实验结果表明。氚进入机体属迅速而均匀地分布于全身各脏器, 并在经历了大约l～8天的蓄积期之后约有l～8%的氚转化为组织结合氚。无论是湿组织中的总氚, 还是干组织中的组织结合氚, 其滞留系数曲线一般都能表述为两项措致函数。总氚的第一生物半排出期约2天。在本实验用量条件下, 每注入l徽居里, 克体重的氚水将在65天内使各脏器受到0.8拉德左右的剂量, 其中组织结台氘的贡献j般不大于1q%.氚在脂肪组织中的行径和其他各脏器不同, 总氚及其所致剂量要低得多, 但组织结合氚所占的比例却要高得多。 |
| 英文摘要: |
| Employing a method of HClO4-H2O2 digestion and liquid scintillation counting, the distribution and retention of tritium in vari ous wet and dry routine tissues within 65 days after inttaperitoneal administration of tritiated water(THO)were investigated, and the radiation dose was。Estimated.HTO was distributed rapidly and uniformly in the whole body.About 1-3%of tritium was incorporated into various tissues as tisaue-bonnd tritium(TBT)after undergoing a accumulation process of about 1-3 days.The retention fraction curves for both total tritium in we;tissues and TBTin drytissuescould be generally expressed as two exponential components.The first biological half-life of total tritium is about 2 days.Under the experimantal condition, the radiation dose to vari-ous tissues during 65 days was about 0.8 rad per μCi/g.B.W., and the contribution of TBT was usually not more then 10% of total tritium.The behavior of tritium in fat tissues was different from that in other tissues. |
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