| 罗梅初,沈彬源,俞志昌,阮天明,张美珍,李兰娣,童顺高,陈桂宝,王风仙.S168对放射性锶的促排效果和药理研究[J].中华放射医学与防护杂志,1985,5(1):6-10 |
| S168对放射性锶的促排效果和药理研究 |
| Rediostrontium Decorporation Effect and Pharmacologic Actions of S168 |
| 投稿时间：1981-09-12 |
| DOI： |
| 中文关键词: 络合剂 放射性核素 锶－85 促排药 乙酰胺基丙叉二磷酸 |
| 英文关键词:chdating agent radionuclide strontium-85 removal drug acetamidopropane diphosphonie acid |
| 基金项目: |
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| 摘要点击次数: 2348 |
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| 中文摘要: |
| 新络合剂S168(乙酰胺基丙叉二膦酸)对放射性锶有较好的促排效果。肌注S168可使大鼠体内的85Sr由尿排出50%以上, 为相同剂量的BADE和BAI冷尿锣排出量的1.5倍。增加S168剂量, 尿85Sr排出可高达70%, 但延缓给药时间效果降低。S168的促排效果与剥量呈线性关系, Y尿带=4.13+0.078X。S168合用中。(鸡内金)能提高疗效, 呈现两药相加作用。本文还详细介绍了S168在小鼠、大鼠和狗身上进行药理研究的结果。 |
| 英文摘要: |
| A new chelating agent, S168 (1-aceta-midopropanc 1, 1-diphosphonic acid), is Proved to be more effective than other agents for removing radiostrontium from rats. Intramuscular injection of S168 immediately after intoxication of rats by 85Sr(IV) in Creased the urinary excretion of 85Sr over 50% of the intoxication dose.The effect of S168 was 1.5 times more potent than BADE and BADS at the same dosage level.The urinary excretion of 85Sr could be raised up to 70% with increasing dosage, hut was sharply reduced when the treatment was delayed. The following linear equation shows the relationship between the effectiveness of 85Sr removal and the dose of S168 Y(urine)=4.13+0.078X.The additive action for 85Sr removal was observed by combination of S168 with Zhong-6 decoctum after 85Sr injection。The pharmacologic actions of S168 on different kind of animals (mice, rats and dogs)are also reported. |
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